SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Polašek Ozren) ;pers:(Lindgren Cecilia M.);mspu:(article);lar1:(su)"

Sökning: WFRF:(Polašek Ozren) > Lindgren Cecilia M. > Tidskriftsartikel > Stockholms universitet

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Evangelou, Evangelos, et al. (författare)
  • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
  • 2018
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
  • Tidskriftsartikel (refereegranskat)abstract
    • High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
  •  
2.
  • Wessel, Jennifer, et al. (författare)
  • Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
  • 2015
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6
  • Tidskriftsartikel (refereegranskat)abstract
    • Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF = 1.4%) with lower FG (beta = -0.09 +/- 0.01 mmol l(-1), P = 3.4 x 10(-12)), T2D risk (OR[95% CI] = 0.86[0.76-0.96], P = 0.010), early insulin secretion (beta = -0.07 +/- 0.035 pmol(insulin) mmol(glucose)(-1), P = 0.048), but higher 2-h glucose (beta = 0.16 +/- 0.05 mmol l(-1), P = 4.3 x 10(-4)). We identify a gene-based association with FG at G6PC2 (p(SKAT) = 6.8 x 10(-6)) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF = 20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (beta = 0.02 +/- 0.004 mmol l(-1), P = 1.3 x 10(-8)). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel  (2)Ta bort avgränsningen
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Rudan, Igor (2)
Wareham, Nicholas J. (2)
Laakso, Markku (2)
Ridker, Paul M. (2)
Chasman, Daniel I. (2)
Amin, Najaf (2)
visa fler...
van Duijn, Cornelia ... (2)
Langenberg, Claudia (2)
Boehnke, Michael (2)
Hamsten, Anders (2)
Scott, Robert A (2)
Rotter, Jerome I. (2)
Oostra, Ben A. (2)
Padmanabhan, Sandosh (2)
Zhao, Jing Hua (2)
Huffman, Jennifer E (2)
Harris, Tamara B (2)
Launer, Lenore J (2)
Liu, Yongmei (2)
Loos, Ruth J F (2)
Hofman, Albert (2)
Uitterlinden, André ... (2)
Morrison, Alanna C (2)
Psaty, Bruce M (2)
Hayward, Caroline (2)
Gudnason, Vilmundur (2)
Zeggini, Eleftheria (2)
Polasek, Ozren (2)
Franco, Oscar H. (2)
O'Donnell, Christoph ... (2)
Boerwinkle, Eric (2)
Watkins, Hugh (2)
Goel, Anuj (2)
Smith, Albert V (2)
Strawbridge, Rona J. (2)
Bis, Joshua C. (2)
Lu, Yingchang (2)
Taylor, Kent D. (2)
Frånberg, Mattias (2)
Levy, Daniel (2)
Bottinger, Erwin P. (2)
Nalls, Mike A. (2)
Giulianini, Franco (2)
Toniolo, Daniela (2)
Traglia, Michela (2)
Guo, Xiuqing (2)
Willems, Sara M. (2)
Ehret, Georg B. (2)
Sala, Cinzia F (2)
visa färre...
Lärosäte
Uppsala universitet (2)
Stockholms universitet  (2)Ta bort avgränsningen
Lunds universitet (2)
Karolinska Institutet (2)
Umeå universitet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (2)
Medicin och hälsovetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy